At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Prospective, Randomized, Double-Blind, Double-Dummy, Multicenter Trial to Assess Safety of Single Dose vs. Traditional Administration of Thymoglobulin Induction for Renal Transplantation
In Brief
A Phase 2 clinical trial evaluating Single-dose rabbit Anti-thymocyte Globulin induction and Divided-dose rabbit Anti-thymocyte Globulin induction for End-Stage Renal Disease and Kidney Failure. Completed, enrolled 99 participants across 4 sites.
Detailed Summary
In a non-blinded pilot study conducted at the University of Nebraska Medical Center, evidence was found that a single large dose of Thymoglobulin on the day of kidney transplantation produced better kidney function than the standard dosing plan, when the same amount is divided into smaller doses on 4 days. This new study repeats that dose comparison, but with double-blinding and at multiple transplantation centers.
Study Details
Timeline
Interventions
6 mg of rATG administered in a single dose on the day of kidney transplantation
6 mg/kg total rabbit Anti-thymocyte Globulin dose administered as 1.5 mg/kg doses on 4 sequential days, beginning on the day of kidney transplantation.