At a glance

ClinicalIndex Comparison Record

N/ACompleted· 46 enrolled

Drug / intervention

benazepril +1 moredrug

Likely dose

benazepril 10 mgfrom record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00907374

NCT00907374N/ACompleted

Compare CT.gov

Early Nephropathy Study in Diabetes With Inhibitory Renin-Angiotensin-Aldosterone System Therapy (END-IT)

Charles Drew University of Medicine and Science·interventional·Posted May 22, 2009·Updated Mar 30, 2012

In Brief

A clinical study evaluating benazepril for Microalbuminuria. Completed, enrolled 46 participants across 1 site.

Detailed Summary

The objective of the study is to assess the effect of standard versus aggressive inhibition of the renin-angiotensin system (RAS)in type 2 diabetic patients with microalbuminuria (MA) on; a)progression of microalbuminuria, b)estimated glomerular filtration rate (eGFR), c)endothelial dysfunction (measured by post-hyperemia arterial tonometry) and d)the slowing of the progression of atherosclerotic disease (measured by carotid intima media thickness \[CIMT\]).

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsMicroalbuminuria

CountriesUnited States

Collaborators--

Timeline

N/ACompletedFinished

20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Enrollment StartJul 2005

Primary CompletionApr 2009

First PostedMay 2009

TodayJul 2026

First PostedMay 22, 2009

Enrollment StartJul 1, 2005

Primary CompletionApr 1, 2009

TodayJul 2, 2026

Enrollment to primary: 3.8 yearsPosted 17.1 years ago

Interventions

benazeprildrug

benazepril 10 mg orally once daily

benazeprildrug

40-80 mg benazepril plus 25-100 mg losartan orally once or twice daily