CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 50 enrolled
Drug / intervention
Venlafaxine ERT +1 moredrug
Likely dose
Venlafaxine ERT 75mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00909155
NCT00909155N/ACompleted
CompareCT.gov

Non-Invasive Brain Imaging Techniques That Predict Antidepressant Responsiveness and Provide Insights Into the Mechanism of Action of Venlafaxine ER vs. Fluoxetine

University of Wisconsin, Madison·interventional·Posted May 27, 2009·Updated Aug 3, 2018

In Brief

A clinical study evaluating Venlafaxine ERT and Fluoxetine for Major Depressive Disorder. Completed, enrolled 50 participants across 1 site.

Detailed Summary

Do functional brain changes occur during Venlafaxine ER (extended release) versus Fluoxetine treatment and do changes in selective structures, such as the amygdala, predict treatment response?

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Depressive Disorder
CountriesUnited States
CollaboratorsWyeth is now a wholly owned subsidiary of Pfizer

Timeline

N/ACompletedFinished
20022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMay 27, 2009
Enrollment StartJul 1, 2002
Primary CompletionDec 1, 2009
TodayJul 2, 2026
Enrollment to primary: 7.4 yearsPosted 17.1 years ago

Interventions

Venlafaxine ERTdrug

Titrated to a minimum dose of 75mg. Further titration based on clinician assessment at followup visits. Intervention to continue through completion of study (180 days). Initial titration: Days 1-7: 37.5 mg; Days 7-14: 75 mg; Days 15-180: 75-300mg based on clinician assessment. Titration rate is a maximum of 75mg/7d.

Fluoxetinedrug

Titrated to a minimum dose of 20mg. Further titration based on clinician assessment at followup visits. Intervention to continue through completion of study (180 days). Initial titration: Days 1-7: 20mg; Days 7-14: 20mg; Days 15-180: 20-80mg based on clinician assessment. Titration rate is a maximum of 20mg/7d