CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 20 target
Drug / intervention
low tidal volume ventilation +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00910026
NCT00910026N/ACompleted
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Exhaled Breath Condensate (EBC) Collection and Analysis in Mechanically Ventilated ICU Patients: Monitoring of the Influence of Various Tidal Volumes on Lung Inflammatory Biomarkers

Larissa University Hospital·interventional·Posted May 29, 2009·Updated Oct 25, 2013

In Brief

A clinical study evaluating low tidal volume ventilation and high tidal volume ventilation for Inflammation. Completed, enrolled 20 participants across 1 site.

Detailed Summary

The aim of the present study is to evaluate the effect of low (6 ml/kg) and high (12 ml/kg) tidal volume ventilation on inflammatory and oxidative stress biomarkers in the exhaled breath condensate (EBC) of ICU patients without lung injury. As the analysis of EBC is reflecting the composition of epithelial lining fluid (ELF), the study of EBC pH and inflammatory and oxidative stress markers could have the potential for assessing lung inflammation caused by mechanical ventilation. This study also aims to look at the possibility to identify selective profiles of biomarkers that might have a prognostic and/or diagnostic value in the follow up of these patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsInflammation
CountriesGreece
CollaboratorsUniversity of Thessaly

Timeline

N/ACompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedMay 29, 2009
Enrollment StartMay 1, 2009
Primary CompletionSep 1, 2013
TodayJul 2, 2026
Enrollment to primary: 4.3 yearsPosted 17.1 years ago

Interventions

low tidal volume ventilationprocedure

6 ml/kg tidal volume ventilation

high tidal volume ventilationprocedure

12 ml/kg tidal volume ventilation