CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 100 enrolled
Drug / intervention
Ocriplasmin +1 moredrug
Likely dose
Ocriplasmin 125 µgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00913744
NCT00913744Phase 2Completed

A Randomized, Sham-Injection Controlled, Double-Masked, Multicenter Trial of Ocriplasmin Intravitreal Injection for Treatment of Focal Vitreomacular Adhesion in Subjects With Exudative Age-Related Macular Degeneration (AMD)

ThromboGenics·interventional·Posted Jun 4, 2009·Updated Dec 17, 2014

In Brief

A Phase 2 clinical trial evaluating Ocriplasmin and Sham injection for Exudative Age-Related Macular Degeneration and Focal Vitreomacular Adhesion. Completed, enrolled 100 participants across 27 sites in 6 countries.

Detailed Summary

This study will evaluate the safety and efficacy of Ocriplasmin intravitreal injection, in subjects diagnosed with exudative AMD with focal vitreomacular adhesion. Ultimately, it is believed that intravitreal ocriplasmin may offer physicians a safe agent for pharmacologic vitreolysis and nonsurgical resolution of focal vitreomacular adhesion in AMD subjects where this adhesion may be causally associated with worse prognosis).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, France, Germany, Italy, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
200920102011201220132014201520162017201820192020202120222023202420252026
First PostedJun 4, 2009
Enrollment StartJan 1, 2010
Primary CompletionDec 1, 2012
Study CompletionApr 1, 2013
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 17.1 years ago

Interventions

Ocriplasmindrug

ocriplasmin intravitreal injection (125 µg)

Sham injectiondrug

Sham injection