At a glance
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Intrathecal Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia With Morphine for Elective Caesarean Section: a Randomized Controlled Trial
In Brief
A Phase 4 clinical trial evaluating Bupivacaine, Morphine, and 2 other interventions for Cesarean Section and 2 related conditions. Completed, enrolled 216 participants across 2 sites.
Detailed Summary
The aim of this study is to assess the efficacy of atropine in preventing nausea and vomiting after spinal anesthesia with local anesthetic and morphine for elective Caesarean section. Patients enrolling in the study will be assigned to one of three groups. One will receive a small dose of intrathecal atropine; another will receive small-dose intravenous atropine; the third group will receive placebo.
Study Details
Timeline
Interventions
12.5 mg of a 5 mg/ml hyperbaric solution, intrathecally
200 µg of a 200 µg/ml solution, intrathecally
0.9% NaCl solution 0.1 ml, intrathecally in group Control and IV Atropine 0.1 ml, intravenously in group Control and Intrathecal Atropine
100 µg of a 1 mg/ml preservative-free solution * intrathecally in group Intrathecal Atropine * intravenously in group IV Atropine