At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of the Cardiovascular, Metabolic and Respiratory Effects of Nebivolol and Carvedilol at High Altitude in Healthy Subjects.
In Brief
A Phase 4 clinical trial evaluating placebo, Carvedilol, and 1 other intervention for Hypoxia and 2 related conditions. Completed, enrolled 27 participants across 1 site.
Detailed Summary
Exposure of healthy subjects to high altitude hypoxia elicits changes in cardiovascular, respiratory and metabolic features as weel as in exercise performance similar, for some aspects, to those observed in chronic heart failure. Exposure to high altitude hypoxia represents a suitable model to assess different treatments proposed for this pathological condition. Our aim was to evaluate the impact of two different third-generation beta-blockers used in heart failure (carvedilol and nebivolol) on cardiovascular, respiratory, metabolic profile and on exercise performance at high altitude.
Study Details
Timeline
Interventions
placebo tablet BID
Carvedilol 25 mg tablets. One tablet twice daily.
nebivolol 5 mg tablets. One nebivolol tablet daily. One placebo tablet daily.