At a glance
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Drug-Eluting Bead, Irinotecan (DEBIRI) Therapy of Liver Metastasis From Colon Cancer With Concomitant Systemic Oxaliplatin, Fluorouracil and Leucovorin Chemotherapy, and Anti-Angiogenic Therapy
In Brief
A Phase 2 clinical trial evaluating LC beads loaded with Irinotecan, Oxaliplatin, and 3 other interventions for Colon Cancer With Metastases to the Liver. Completed, enrolled 70 participants across 10 sites in 2 countries.
Detailed Summary
This is a multicentre, open labeled, controlled phase study designed to assess effectiveness of chemoembolization with LC Beads, both with and without systemic chemotherapy, in the treatment of unresectable liver metastases in patients with colorectal cancer.
Study Details
Timeline
Interventions
Chemoembolization using LC beads loaded with 100mg Irinotecan
Oxaliplatin 85 mg/sqm, IV infusion every two weeks
Leucovorin 200 mg/sqm, IV infusion every two weeks
5-Fluorouracil 2400 mg/sqm, IV infusion every 2 week
Bevacizumab 5 mg/kg given at the discretion of the treating physician