At a glance
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A Phase II Study of Carboplatin (CBDCA), Paclitaxel (TAXOL), and Everolimus (RAD001) in Previously Untreated Patients With Measurable Disease With Cancer of Unknown Primary (CUP)
In Brief
A Phase 2 clinical trial evaluating carboplatin, everolimus, and 1 other intervention for Carcinoma of Unknown Primary Origin. Completed, enrolled 46 participants across 141 sites.
Detailed Summary
RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well carboplatin given together with paclitaxel and everolimus works in treating patients with previously untreated cancer of unknown primary.
Study Details
Timeline
Interventions
Given IV
Given PO
Given IV