CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 62 enrolled
Drug / intervention
Sodium Nitroprusside +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00945256
NCT00945256Phase 1Completed
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A Phase I Trial Examining Muscle Perfusion and Protein Metabolism in Elderly and Young

The University of Texas Medical Branch, Galveston·interventional·Posted Jul 24, 2009·Updated Feb 3, 2016

In Brief

A Phase 1 clinical trial evaluating Aerobic Exercise, Sodium Nitroprusside, and 1 other intervention for Aging. Completed, enrolled 62 participants.

Detailed Summary

The purpose of this study was to examine the role skeletal muscle perfusion plays in mediating muscle protein synthesis in healthy older and younger individuals. The investigators hypothesized that normalization of muscle perfusion in older men and women via exercise or infusion of a vasodilator would enhance nutritive flow and skeletal muscle protein synthesis in the elderly similar to that of their younger counterparts.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAging
Countries--
CollaboratorsNational Institute on Aging (NIA)

Timeline

Phase 1CompletedFinished
2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJul 24, 2009
Enrollment StartMay 1, 2003
Primary CompletionMay 1, 2008
Study CompletionMay 1, 2009
TodayJul 2, 2026
Enrollment to primary: 5 yearsPosted 16.9 years ago

Interventions

Aerobic Exerciseother

45 minuties of treadmill walking was completed at 40% VO2 peak

Sodium Nitroprussidedrug

Sodium Nitroprusside was given in a constant infusion for 180 minutes at a rate of 0.114 ug/kg/min

Amino Acid Drinkdietary

7.5 gram Amino Acid drink