At a glance
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The Role of Endorphins in the Perception of Dyspnea With Resistive Loading in Patients With COPD
In Brief
A clinical study evaluating naloxone and normal saline for Chronic Obstructive Pulmonary Disease. Completed, enrolled 14 participants across 1 site.
Detailed Summary
Endorphins are released in response to breathing difficulty and can modify the perception of breathlessness. In this randomized placebo-controlled trial, resistive breathing loads are used to provoke breathlessness in patients with chronic obstructive pulmonary disease. The hypothesis of the study is that intravenous (IV) administration of naloxone, a medication which blocks endorphin activity, will increase the perception of breathlessness experienced by patients while breathing through a resistance device, compared with IV administration of normal saline.
Study Details
Timeline
Interventions
10 mg naloxone in 25 ml total volume
25 ml