At a glance
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A Placebo-controlled Trial of D-cycloserine Augmentation of Cognitive Remediation in Schizophrenia
In Brief
A clinical study evaluating D-cycloserine, Placebo, and 1 other intervention for Schizophrenia. Completed, enrolled 54 participants across 1 site.
Detailed Summary
This study seeks to examine the effects of D-cycloserine augmentation on cognitive remediation for patients diagnosed with schizophrenia. We will test the hypotheses that D-cycloserine will significantly improve cognitive performance, negative symptoms, and measures of functioning compared to placebo when combined with eight weeks of cognitive remediation. We expect that these effects will persist when assessed at six-month follow up.
Study Details
Timeline
Interventions
50 mg by mouth one hour before first cognitive remediation session each week for eight weeks.
Placebo by mouth one hour before first cognitive remediation session each week for eight weeks.
40 one-hour daily sessions of cognitive remediation (Brain Fitness Program) over eight weeks.