CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 142 enrolled
Drug / intervention
desipramine hydrochloride +4 moredrug
Likely dose
benztropine mesylate 0.125 mg dailyfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00964886
NCT00964886Phase 2Completed
CompareCT.gov

Efficacy of Antidepressants in Chronic Back Pain

VA Office of Research and Development·interventional·Posted Aug 25, 2009·Updated Nov 29, 2016

In Brief

A Phase 2 clinical trial evaluating cognitive behavioral therapy, desipramine hydrochloride, and 1 other intervention for Back Pain. Completed, enrolled 142 participants across 1 site.

Detailed Summary

This 12 week placebo controlled clinical trial tests the individual and combined effects of an antidepressant medication and cognitive behavioral therapy for chronic back pain.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBack Pain
CountriesUnited States
CollaboratorsUniversity of California, San Diego

Timeline

Phase 2CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedAug 25, 2009
Enrollment StartJan 1, 2010
Primary CompletionDec 1, 2014
Study CompletionDec 1, 2015
TodayJul 2, 2026
Enrollment to primary: 4.9 yearsPosted 16.9 years ago

Interventions

cognitive behavioral therapybehavioral

cognitive behavioral therapy, a type of psychotherapy oriented towards restoring function and reducing impact of pain on everyday life

desipramine hydrochloridedrug

desipramine hydrochloride, with dose targeted to achieve a serum concentration of 5-60ng/ml

cognitive behavioral therapybehavioral

cognitive behavioral therapy, a type of psychotherapy oriented towards restoring function and reducing impact of pain on everyday life

benztropine mesylate 0.125 mg dailydrug

benztropine mesylate is a placebo, some of whose side effects mimic those of experimental intervention, desipramine hydrochloride

desipramine hydrochloridedrug

desipramine hydrochloride, with dose targeted to achieve a serum concentration of 5-60ng/ml