At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Treatment of Older Adults With Acute Lymphoblastic Leukemia
In Brief
A Phase 2 clinical trial evaluating Prednisone, Vincristine, and 7 other interventions for Acute Lymphoblastic Leukemia. Completed, enrolled 30 participants across 3 sites.
Detailed Summary
The purpose of this study is to determine the safety and effectiveness of a multi-drug regimen (which includes prednisone, vincristine, cytarabine, doxorubicin, 6 mercaptopurine, and methotrexate) which is considered standard treatment for children and young adults with acute lymphoblastic leukemia (ALL), in combination with PEG-asparaginase and clofarabine to treat older adults with ALL. PEG-asparaginase has been used in chemotherapy treatment regimens for both children and adults with ALL. Clofarabine has been used in chemotherapy treatment regimens for children with ALL and has been shown to decrease the number of leukemia cells. Participants with leukemia that has an abnormal chromosome, called the Philadelphia chromosome, will also be given imatinib.
Study Details
Timeline
Interventions
Orally during Induction, Consolidation 1, CNS, Consolidation 2, and Continuation therapy.
Intravenously during Induction, CNS, Consolidation 2 and Continuation Therapy
Intravenously during Induction, CNS, and Consolidation 2 therapy
Intravenously during Induction, Consolidation 1, CNS, and Consolidation 2 therapy
Intrathecally during Induction and CNS therapy
Intrathecally during Induction, CNS, and Continuation Therapy
Orally during Induction, Consolidation 1, CNS, Consolidation 2 and Continuation Therapy
Intravenously during Consolidation 1 Therapy
Orally during CNS, Consolidation 2 and Continuation Therapy