At a glance
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A Randomized, Double-Blinded, Placebo-Controlled Protocol of Oral Cyclosporine in Patients With Advanced Stage Chronic Obstructive Pulmonary Disease
In Brief
A Phase 2 clinical trial evaluating Cyclosporine and Placebo for Chronic Obstructive Pulmonary Disease. Completed, enrolled 43 participants across 1 site.
Detailed Summary
This is a randomized, double-blinded, placebo-controlled trial of oral Cyclosporine A (CsA) in patients with advanced stage chronic obstructive pulmonary disease. The purpose of the study is to evaluate the safety and effectiveness of CsA as a therapy for the adaptive immune response in advanced stage Chronic Obstructive Pulmonary Disease (COPD). Subjects between 45 and 80 years of age with a confirmed diagnosis of advanced stage COPD, not responsive to conventional inhaler therapy, who meet all the study requirements, will be enrolled in this study. A total of 30 subjects of either sex will be enrolled in this study.
Study Details
Timeline
Interventions
Fifteen patients will receive cyclosporine at an initial dosing of 3.0 mg/kg/day.
Fifteen patients will receive will receive placebo.