CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 1,199 enrolled
Drug / intervention
Enzalutamide +1 moredrug
Likely dose
Enzalutamide 160 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00974311
NCT00974311Phase 3Completed

Affirm: A Multinational Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy And Safety Study Of Oral Mdv3100 In Patients With Progressive Castration-resistant Prostate Cancer Previously Treated With Docetaxel Based Chemotherapy

Pfizer·interventional·Posted Sep 10, 2009·Updated Dec 11, 2018

In Brief

A Phase 3 clinical trial evaluating Enzalutamide and Placebo for Castration-Resistant Prostate Cancer. Completed, enrolled 1,199 participants across 249 sites in 15 countries.

Detailed Summary

This is a phase 3 study to compare the clinical benefit of MDV3100 versus placebo in patients with castration-resistant prostate cancer who have been previously treated with docetaxel-based chemotherapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Australia, Austria, Belgium, Canada, Chile, France, Germany, Italy, Netherlands, Poland, South Africa, Spain, United Kingdom, United States

Timeline

Phase 3CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedSep 10, 2009
Enrollment StartSep 30, 2009
Primary CompletionSep 15, 2011
Study CompletionNov 2, 2017
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 16.8 years ago

Interventions

Enzalutamidedrug

MDV3100, 160 mg orally per day

Placebodrug

Placebo comparator