CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 318 enrolled
Drug / intervention
Dietary Weight-loss +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00979043
NCT00979043N/ACompleted
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The Arthritis, Diet, and Activity Promotion Trial

Wake Forest University Health Sciences·interventional·Posted Sep 17, 2009·Updated Apr 14, 2023

In Brief

A clinical study evaluating Dietary Weight-loss and Exercise for Knee Osteoarthritis. Completed, enrolled 318 participants across 1 site.

Detailed Summary

The primary purpose of this study was to determine the effect of dietary weight-loss, exercise training, or a combination of both on physical function in overweight and obese adults with knee osteoarthritis (OA). In secondary analyses, the effect of weight-loss and/or exercise on OA progression, self-reported pain and inflammation were examined. In post-trial analyses, the effect of dietary weight-loss on total mortality was determined.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsKnee Osteoarthritis
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)

Timeline

N/ACompletedFinished
199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 17, 2009
Enrollment StartNov 1, 1997
Primary CompletionDec 1, 2000
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 16.8 years ago

Interventions

Dietary Weight-lossbehavioral

The goal of the dietary weight-loss intervention was to produce and maintain a mean weight-loss of 5% initial body weight during the 18-month intervention, using dietary counseling and behavior modification.

Exercisebehavioral

Participants participated in resistance training (15 minutes) and aerobic exercise (30 minutes) 3d/week for 18-months. The first 4-months of the exercise training were facility-based. After 4-months, participants were allowed to transition to a home-based intervention if they chose to.