CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 74,256 enrolled
Drug / intervention
Chlorhexidine bath and nasal mupirocindrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00980980
NCT00980980N/ACompleted
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Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal

Harvard Pilgrim Health Care·interventional·Posted Sep 21, 2009·Updated May 2, 2017

In Brief

A clinical study evaluating Chlorhexidine bath and nasal mupirocin for Methicillin-resistant Staphylococcus Aureus. Completed, enrolled 74,256 participants across 42 sites.

Detailed Summary

The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units. The three strategies to be evaluated are: * screening on admission followed by isolation of MRSA+ patients * screening on admission followed by isolation and decolonization of MRSA+ patients * universal decolonization on admission with no screening. The decolonization regimen involves bathing with chlorhexidine plus intra-nasal application of mupirocin. The main outcome will be MRSA+ clinical cultures. The study is a partnership between the CDC, the CDC Prevention Epicenters, and the Hospital Corporation of America.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMethicillin-resistant Staphylococcus Aureus
CountriesUnited States
CollaboratorsAgency for Healthcare Research and Quality (AHRQ), Centers for Disease Control and Prevention, Hospital Corporation of America, University of California, Irvine, Department of Population Medicine, Harvard Medical School / Harvard Pilgrim Healthcare Institute

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedSep 21, 2009
Enrollment StartSep 1, 2009
Primary CompletionSep 1, 2011
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 16.8 years ago

Interventions

Chlorhexidine bath and nasal mupirocindrug

The intervention / decolonization regimen will consist of the most commonly used topical regimen in the US - a combination of daily baths with 2% chlorhexidine cloths , plus 5 days of topical intranasal mupirocin ointment (bilateral nares, twice daily)