At a glance
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Duloxetine for Treatment of Painful Temporomandibular Joint Disorder
In Brief
A clinical study evaluating duloxetine and Placebo for Temporomandibular Joint Disorders. Completed, enrolled 24 participants across 1 site.
Detailed Summary
Temporomandibular joint disorders (TMJD) are a family of musculoskeletal disorders that represent the most common chronic orofacial pain condition. TMJD is associated with persistent pain in the region of the temporomandibular joint and muscles of the head and neck. The purpose of this study is to test duloxetine (Cymbalta) as a potential treatment for chronic facial pain. Duloxetine is FDA approved as an antidepressant and for the chronic pain conditions of fibromyalgia and diabetic neuropathy. Chronic facial pain may be linked to Temporomandibular Joint Disorder (TMJD) which currently has no standard treatment.
Study Details
Timeline
Interventions
Evaluate the analgesic effect of 30 mg duloxetine twice daily in comparison to matching placebo at baseline (BL) and follow up over a six week period
Placebo match duloxetine for 6 week period.