CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 460 enrolled / 460 target
Drug / intervention
blood pressure maintenance based on cerebral blood flow autoregulation measurement +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00981474
NCT00981474N/ACompletedHigh Momentum (2.3/mo)Completion was 76mo ago

Continuous Cerebral Autoregulation Monitoring to Reduce Brain Injury From Cardiac Surgery

Northwestern University·interventional·Posted Sep 22, 2009·Updated Jun 5, 2026

In Brief

A clinical study evaluating blood pressure maintenance based on cerebral blood flow autoregulation measurement and Control group for Thoracic Surgery and Cardiopulmonary Bypass. Completed, enrolled 460 participants across 1 site.

Signals

Enrolling ahead of pace

Detailed Summary

Neurological complications from cardiac surgery are an important source of operative mortality, prolonged hospitalization, health care expenditure, and impaired quality of life. New strategies of care are needed to avoid rising complications for the growing number of aged patients undergoing cardiac surgery. This study will evaluate novel methods for reducing brain injury during surgery from inadequate brain blood flow using techniques that could be widely employed.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedSep 22, 2009
Enrollment StartSep 1, 2009
Primary CompletionFeb 4, 2020
Study CompletionFeb 28, 2020
TodayJul 2, 2026
Enrollment to primary: 10.4 yearsPosted 16.8 years ago

Arms & Interventions

Controlactive_comparator

Blood pressure targets during cardiopulmonary bypass based on institutional standards of empiric management.

Device: Control group
Interventionexperimental

Blood pressure management based on cerebral autoregulation data.

Drug: blood pressure maintenance based on cerebral blood flow autoregulation measurement

Interventions

blood pressure maintenance based on cerebral blood flow autoregulation measurementdrug

Blood pressure lowered or raised

Control groupdevice

Institutional standard of care.