Antiviral Treatment in Adults and Children With Novel Influenza A (H1N1) Respiratory Tract Infection - a Clinical, Virological and Pharmacokinetic Study.

Detailed Summary

The aims of this study are to characterise the clinical efficacy and virological clearance dynamics of orally administered oseltamivir in patients with influenza caused by novel influenza A(H1N1). This research will also contribute to enhancing research capacity in affected countries. The objectives are to assess the: * viral replication levels over time in affected patients * antiviral efficacy of oral oseltamivir * patterns and compartments of viral shedding, tissue distribution * innate inflammatory response and relation to viral replication * kinetics of antibody response * antiviral sensitivity of influenza viruses at baseline and during oseltamivir treatment using in vitro and molecular methods * pharmacokinetic characteristics of oseltamivir and oseltamivir carboxylate * all cause in hospital mortality * clinical and radiological features, disease course and outcome * length of stay in hospital * risk factors associated with development of severe disease and death

Study Details

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