At a glance
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Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome
In Brief
A clinical study evaluating 3-D Ultrasound, recombinant human chorionic gonadotropin, and 4 other interventions for Polycystic Ovary Syndrome. Completed, enrolled 41 participants across 1 site.
Detailed Summary
Jeffrey Chang MD is conducting a research study to learn more about the increased male hormone levels, otherwise known as androgens, seen in women with polycystic ovary syndrome (PCOS). Women with PCOS have ovaries that are comprised of many cysts, or follicles. They also have irregular or absent menstrual periods and symptoms of increased male hormones, such as facial hair or acne. In each part of the study (except part 4 which is for PCOS women only) we will be comparing responses of PCOS women to normal controls
Study Details
Timeline
Interventions
One time pelvic ultrasound
Recombinant human chorionic gonadotropin will be given iv and blood samples obtained before and 24 hr afterwards
Recombinant human follicle stimulating hormone will be given iv and blood samples obtained before and 24 hr later.
Each subject will receive a 7 hr dose-response infusion of Adrenocorticotropin.
Dexamethasone will be given prior to ACTH infusion test.
Each subject will undergo 3 oral glcuose tolerance tests.