CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 67 enrolled
Drug / intervention
prazosin hydrochloride +1 moredrug
Likely dose
prazosin hydrochloride 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00990106
NCT00990106N/ACompleted
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A Placebo-Controlled Augmentation Trial of Prazosin for PTSD

Seattle Institute for Biomedical and Clinical Research·interventional·Posted Oct 6, 2009·Updated May 23, 2018

In Brief

A clinical study evaluating prazosin hydrochloride and placebo for Stress Disorders, Post-Traumatic and 2 related conditions. Completed, enrolled 67 participants across 2 sites.

Detailed Summary

The purpose of this study is to determine whether prazosin will: * reduce the incidence of nightmares and sleep disturbance * increase functioning and sense of well being in combat-trauma exposed Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Veterans.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStress Disorders, Post-Traumatic, Combat Disorders, Sleep Disorders
CountriesUnited States
CollaboratorsUnited States Department of Defense, VA Puget Sound Health Care System, National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedOct 6, 2009
Enrollment StartSep 1, 2009
Primary CompletionMar 1, 2013
TodayJul 2, 2026
Enrollment to primary: 3.5 yearsPosted 16.7 years ago

Interventions

prazosin hydrochloridedrug

Subject will be titrated up to the optimum tolerated dose based on the Dosing Algorithm. Males and females will be titrated differently with females titrated slower and to a lower maximum daily dose. The first dose will be taken while the participant is in bed for the night to avoid orthostatic syncope, an uncommon but recognized "first dose" effect of prazosin or any alpha-1 antagonist if started at a high dose. The first dose effect is avoidable by starting treatment with a low dose (1 mg at bedtime) then titrating the dose upward gradually.

placebodrug

placebo