At a glance
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Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
In Brief
A clinical study evaluating 5% dextrose, Vitamin C, and 2 other interventions for Hyperglycemia. Completed, enrolled 59 participants across 1 site.
Detailed Summary
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and then a re-establishment of flow. The blood vessel lining plays a key role in this injury. This research will examine, in human volunteers, several important modifiers of APC in human blood vessels: high blood sugar, vitamin C, and statin drugs. Thus, the proposed studies will advance the investigators' understanding of mechanisms of this injury in humans and explore important modifiers of APC protection from injury.
Study Details
Timeline
Interventions
Glucose is infused to prevent the anesthetic preconditioning (sevoflurane) protection against subsequent ischemia/reperfusion injury.
Vitamin C is intended to restore the impairment of the endothelium caused by the dextrose infusion.
Simvastatin will be ingested to determine the efficacy of a statin to modulate the forearm response to glucose.
Sevoflurane will be given to attenuate or prevent the I/R injury during glucose.