CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 16 enrolled
Drug / intervention
Dobutamine stress echo (DSE) +1 moredrug
Likely dose
Atropine bolus 0.5 milligramsfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00998205
NCT00998205N/ACompleted
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Early Diagnosis of Diastolic Dysfunction and Reliability of Dobutamine Stress Echo (DSE) in Detecting Stress Diastolic Dysfunction

University of Missouri-Columbia·interventional·Posted Oct 20, 2009·Updated Apr 6, 2017

In Brief

A clinical study evaluating Dobutamine stress echo (DSE) and Atropine bolus for Diastolic Dysfunction. Completed, enrolled 16 participants across 1 site.

Detailed Summary

The heart becoming "stiff" due to increased fibrous tissue or decreased elasticity of the heart tissue is one of the earliest changes caused by heart failure. These changes can be detected by simple non-invasive echocardiogram techniques. However, these techniques usually detect the increased "stiffness" of the heart only after it has progressed to a significant extent. The investigators hypothesize that if they stress the heart using a Dobutamine infusion and measure the filling pressure using echocardiogram, it will provide them with tools to identify these changes earlier.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDiastolic Dysfunction
CountriesUnited States
CollaboratorsKansas City Veteran Affairs Medical Center

Timeline

N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 20, 2009
Enrollment StartJun 1, 2008
Primary CompletionJan 1, 2011
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 16.7 years ago

Interventions

Dobutamine stress echo (DSE)drug

Dobutamine intravenous infusion would be undertaken starting at 10 micro-grams/kg per minute in three minute intervals increased to 20, 30, 40 or 50 micro-grams/kg per minute or to a peak heart rate response of at least 85% age predicted maximum heart rate.

Atropine bolusdrug

If at the end of the Dobutamine protocol, there is inadequate heart rate response, intravenous atropine boluses of 0.5 milligrams (maximum 1.0 mg) would be used as needed to achieve a heart rate of at least 85% of age predicted maximum heart rate.