CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 9 enrolled
Drug / intervention
Aprepitant 0mg +8 moredrug
Likely dose
Aprepitant 0mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00999544
NCT00999544N/ACompleted
CompareCT.gov

New Neural Drug Targets: An Evaluation of the Effects of Aprepitant on the Response to Oxycodone

Sharon Walsh·interventional·Posted Oct 21, 2009·Updated Sep 1, 2017

In Brief

A clinical study evaluating Aprepitant 0mg, Aprepitant 40mg, and 7 other interventions for Narcotic Abuse. Completed, enrolled 9 participants across 1 site.

Detailed Summary

Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain. Recent preclinical data suggest a role for Substance P (NK-1) receptors in modulating both the acute and chronic response to opioids. The objective of this study is to determine whether pretreatment with aprepitant, a selective neurokinin-1 (NK-1) antagonist can reduce the direct response to an opioid agonist (oxycodone) on measures related to abuse liability and reinforcing effects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNarcotic Abuse
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA), Merck Sharp & Dohme LLC

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedOct 21, 2009
Enrollment StartOct 1, 2009
Primary CompletionApr 1, 2011
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 16.7 years ago

Interventions

Aprepitant 0mgdrug

Aprepitant 0mg, p.o. pretreatment

Aprepitant 40mgdrug

Aprepitant 40mg, p.o. pretreatment

Aprepitant 200mgdrug

Aprepitant 200mg, p.o. pretreatment

Oxycodone 0mg, p.o.drug

Oxycodone 0mg, p.o.

Oxycodone 20mg, p.o.drug

Oxycodone 20mg, p.o.

Oxycodone 40mg, p.o.drug

Oxycodone 40mg, p.o.

Oxycodone 0mg, INdrug

Oxycodone 0mg, IN

Oxycodone 15mg, INdrug

Oxycodone 15mg, IN

Oxycodone 30mg, INdrug

Oxycodone 30mg, IN