CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 67 enrolled
Drug / intervention
Sevoflurane +1 moredrug
Likely dose
Propofol 2.5 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01000337
NCT01000337N/ACompleted
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The Impact of Sevoflurane and Propofol Anesthesia on Hepatic Apoptosis Markers

University of Athens·interventional·Posted Oct 23, 2009·Updated May 19, 2017

In Brief

A clinical study evaluating Sevoflurane and Propofol for Liver Dysfunction. Completed, enrolled 67 participants across 1 site.

Detailed Summary

Anesthesia may affect the function of vital organs. Liver is one of them. The investigator's hypothesis is that intravenous or inhalation anesthesia does not impair liver function as assessed by more elegant tests like markers indicating liver apoptosis. In the present randomized prospective trial female patients scheduled for mastectomy or thyroidectomy will receive inhalation or total intravenous anesthesia and markers for liver dysfunction will be determined.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLiver Dysfunction
CountriesGreece
Collaborators--

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedOct 23, 2009
Enrollment StartOct 1, 2009
Primary CompletionNov 1, 2011
Study CompletionApr 1, 2012
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 16.7 years ago

Interventions

Sevofluranedrug

Sevoflurane concentration for induction of anesthesia 7-8%, for maintenance of anesthesia 2%.

Propofoldrug

Propofol to induce anesthesia 2.5 mg/kg, for maintenance of anesthesia 6 mg/kg/h