At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Target Temperature Management 33°C Versus 36°C After Out-of-hospital Cardiac Arrest, a Randomised, Parallel Groups, Assessor Blinded Clinical Trial
In Brief
A clinical study evaluating Target temperature 36°C and Target Temperature 33°C for Out-of-hospital Cardiac Arrest. Completed, enrolled 950 participants across 33 sites in 10 countries.
Detailed Summary
Experimental studies and previous clinical trials suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest. However, the accrued evidence is inconclusive and associated with risks of systematic error, design error and random error. Elevated body temperature after cardiac arrest is associated with a worse outcome. Previous trials did not treat elevated body temperature in the control groups. The optimal target temperature for post-resuscitation care is not known. The primary purpose with the TTM-trial is to evaluate if there are differences in all-cause mortality, neurological function and adverse events between a target temperature management at 33°C and 36°C for 24 hours following return of spontaneous circulation after cardiac arrest.
Study Details
Timeline
Interventions
In hospital target temperature management to achieve a core body temperature of 36°C for 24 hours
In hospital target temperature management to achieve a core body temperature of 33°C for 24 hours