CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 613 enrolled
Drug / intervention
Everolimus and tacrolimus +1 moredrug
Likely dose
Everolimus and tacrolimus 0.75 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01025817
NCT01025817Phase 3Completed

A 12 Month, Multi-center, Randomized, Open-label Non-inferiority Study Comparing Safety and Efficacy of Concentration-controlled Everolimus With Low Dose Tacrolimus to Mycophenolate Mofetil With Standard Dose Tacrolimus in de Novo Renal Transplant Recipients

Novartis Pharmaceuticals·interventional·Posted Dec 4, 2009·Updated Nov 11, 2015

In Brief

A Phase 3 clinical trial evaluating Everolimus and tacrolimus and mycophenolate mofetil and tacrolimus for Kidney Transplant. Completed, enrolled 613 participants across 50 sites in 2 countries.

Detailed Summary

The purpose of this phase 3b study is to compare the safety and efficacy of everolimus with low dose tacrolimus to mycophenolate mofetil with standard dose tacrolimus in kidney transplant recipients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedDec 4, 2009
Enrollment StartJan 1, 2010
Primary CompletionMar 1, 2013
TodayJul 2, 2026
Enrollment to primary: 3.2 yearsPosted 16.6 years ago

Interventions

Everolimus and tacrolimusdrug

Everolimus: * Dosage form: 0.75 mg, 0.25 mg, and 0.5 mg tablets * Dose: 1.5 mg per day * Frequency: 0.75 mg twice daily Tacrolimus: * Dose adjusted to maintain specific blood levels

mycophenolate mofetil and tacrolimusdrug

Mycophenolate mofetil: - Dose form: 250 mg capsule - Dose: 2g per day - Frequency: 1g twice daily Tacrolimus: - Dose adjusted to maintain specific blood levels