CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 166 enrolled
Drug / intervention
bleomycin sulfate +8 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01026220
NCT01026220Phase 3Completed
CompareCT.gov

A Non-Randomized Phase III Study of Response Adapted Therapy for the Treatment of Children With Newly Diagnosed High Risk Hodgkin Lymphoma

Children's Oncology Group·interventional·Posted Dec 4, 2009·Updated Apr 28, 2022

In Brief

A Phase 3 clinical trial evaluating bleomycin sulfate, doxorubicin hydrochloride, and 7 other interventions for Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma and 2 related conditions. Completed, enrolled 166 participants across 177 sites in 5 countries.

Detailed Summary

This phase III trial is studying how well giving combination chemotherapy together with radiation therapy works in treating young patients with newly diagnosed Hodgkin lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high energy x-rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChildhood Nodular Lymphocyte Predominant Hodgkin Lymphoma, Stage III Childhood Hodgkin Lymphoma, Stage IV Childhood Hodgkin Lymphoma
CountriesAustralia, Canada, Israel, Puerto Rico, United States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 3CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedDec 4, 2009
Enrollment StartDec 7, 2009
Primary CompletionMar 1, 2012
Study CompletionMar 31, 2022
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 16.6 years ago

Interventions

bleomycin sulfatebiological

Given IV or SC

doxorubicin hydrochloridedrug

Given IV

liposomal vincristine sulfatedrug

Given IV

vinorelbine tartratedrug

Given IV

cyclophosphamidedrug

Given IV

etoposide phosphatedrug

Given IV

prednisonedrug

Given IV

filgrastimbiological

Given IV or SC

ifosfamidedrug

Given IV