CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 50 enrolled
Drug / intervention
furosemide and hypertonic saline solution +1 moredrug
Likely dose
furosemide and hypertonic saline solution 500 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01028170
NCT01028170Phase 3Completed
CompareCT.gov

Assessing the Renal Consequences and Functional Efficacy of Low Dose Hypertonic Saline Solution and Furosemide for the Treatment of Congestive Heart Failure in a Randomized, Double Blind, Prospective Study

Aspirus Heart and Vascular Institute-Research and Education·interventional·Posted Dec 9, 2009·Updated Feb 9, 2012

In Brief

A Phase 3 clinical trial evaluating furosemide and hypertonic saline solution and furosemide for Congestive Heart Failure and Renal Insufficiency. Completed, enrolled 50 participants across 1 site.

Detailed Summary

The purpose of this study is to compare high dose furosemide in combination with low volume hypertonic saline solution (2.4%) with intermittent pulse dose furosemide in patients with pre treatment kidney function impairment. The hypothesis is that it will provide effective diuretic response and have a beneficial effect on preservation of renal function as compared to pulse furosemide in patients with pre-treatment renal impairment (GFR \< 60 mL/min).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCongestive Heart Failure, Renal Insufficiency
CountriesUnited States
CollaboratorsAspirus Wausau Hospital

Timeline

Phase 3CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedDec 9, 2009
Enrollment StartNov 1, 2009
Primary CompletionJul 1, 2011
Study CompletionJan 1, 2012
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 16.6 years ago

Interventions

furosemide and hypertonic saline solutiondrug

250-500 mg furosemide (30 min IV Q 12 hours) with 150 mL of 2.4% NaCl

furosemidedrug

80-160 mg furosemide (Given over 5 min IV twice a day)