CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 206 enrolled
Drug / intervention
IV cefazolin plus oral probenecid and placebo cephalexin +1 moredrug
Likely dose
IV cefazolin plus oral probenecid and placebo cephalexin 2 gfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01029782
NCT01029782Phase 2Completed
CompareCT.gov

Intravenous Cefazolin Plus Oral Probenecid vs. Oral Cephalexin for the Treatment of Cellulitis: a Randomized Controlled Trial

Kelowna General Hospital·interventional·Posted Dec 10, 2009·Updated Aug 13, 2018

In Brief

A Phase 2 clinical trial evaluating IV cefazolin plus oral probenecid and placebo cephalexin and Oral cephalexin and saline IV plus probenecid placebo for Cellulitis. Completed, enrolled 206 participants across 2 sites.

Detailed Summary

The purpose of this study is to determine whether oral cephalexin is equivalent to intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft tissue infections in patients that present to the emergency department.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCellulitis
CountriesCanada
CollaboratorsCanadian Society of Hospital Pharmacists, Capital Health, Canada, Interior Health Authority, Canada

Timeline

Phase 2CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedDec 10, 2009
Enrollment StartMay 1, 2010
Primary CompletionOct 1, 2014
TodayJul 2, 2026
Enrollment to primary: 4.4 yearsPosted 16.6 years ago

Interventions

IV cefazolin plus oral probenecid and placebo cephalexindrug

Intravenous cefazolin 2 g IV plus probenecid 1 g daily plus cephalexin placebo orally four times daily.

Oral cephalexin and saline IV plus probenecid placebodrug

Cephalexin 500 mg orally four times daily plus saline IV and oral probenecid placebo daily