At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phenotypic Characterization and Array CGH Analysis in Patients With Syndromic Obesity of Unknown Etiology
In Brief
A clinical study evaluating Clinical examination and blood sampling for biological and genetic analysis for Mental Retardation and Syndromic Obesity. Completed, enrolled 90 participants across 6 sites.
Detailed Summary
Comparative genomic hybridization (CGH) array technology has been used in numerous studies on mental retardation, and few chromosomal abnormalities have been identified in patients. Because chromosomal abnormalities have still been associated with obesity, we can expect that syndromic obesity is also associated with small deletions/duplications. Characterization of deleted or duplicated loci in these obese patients would mean that these loci include genes implicated in obesity. This will permit to propose new gene(s) involved in obesity. (In french: Caractérisation phénotypique et recherche de REManiements chromosomiques chez des patients présentant une OBésité syndromique de cause non identifiée : REMOB)
Study Details
Timeline
Interventions
Clinical examination and precise description of the phenotype (questionnaire) * Standardized screening with : * radiological (hands, feet, spine ; and renal ultrasonography) * biological (hormonal, metabolic, and "basic" genetic investigations (karyotype, FISH 22q11.2, Fragile X, and other depending on the clinical data))