At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Pilot Study to Evaluate the Effects of Purple Grape Juice on the Vascular Health of Childhood Cancer Survivors
In Brief
A Phase 1 clinical trial evaluating Purple Grape Juice and Apple Juice for Cardiovascular Disease. Completed, enrolled 24 participants across 1 site.
Detailed Summary
Rationale: Survivors of childhood cancer are at an increased risk of developing cardiovascular risk factors as well as early cardiovascular disease, likely due to the intensive therapeutic regimen used to treat their cancer. Purple grape juice (PGJ) is a rich source of flavonoids and a powerful antioxidant. Clinical studies in both diseased and healthy adults suggest that daily consumption of PGJ contributes to increased antioxidant capacity, reduced low-density lipoprotein (LDL) oxidation, and improved vasodilation. Purpose: This randomized clinical trial is evaluating whether purple grape juice can reduce oxidative stress and improve the vascular health of survivors of childhood cancer in the early stages of cardiovascular disease.
Study Details
Timeline
Interventions
6 ounces of purple grape juice consumed twice daily either during first or second 4 week supplementation period, depending on sequence randomization
6 ounces of clear apple juice consumed twice daily either during first or second 4 week supplementation period, depending on sequence randomization