At a glance
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The Effect of Exercise on Acute Nicotine Withdrawal: Human Study
In Brief
A clinical study evaluating Exercise for Nicotine Dependence and 2 related conditions. Completed, enrolled 88 participants across 1 site.
Detailed Summary
The primary aim of this project is to test the effect of exercise on acute nicotine withdrawal. Acute nicotine withdrawal is characterized by a complex array of symptoms associated with increased risk of relapse among individuals attempting smoking cessation. The available remedies do not target all aspects of withdrawal. For example, pharmacologic treatments reduce withdrawal-based craving, but have no effect on cue-related craving, altered sleep, and mood disturbances during withdrawal. Therefore, non-pharmacologic behavioral techniques with the potential to attenuate persistent withdrawal symptoms are needed. We hypothesized that exercise can be a valid non-pharmacologic strategy to improve these domains.
Study Details
Timeline
Interventions
Each 3-day experimental period will include one of the following conditions: 1. Morning exercise - subject will exercise on each of the three mornings in the sleep laboratory, starting 30 minutes after their habitual rise-time; 2. Evening exercise - subject will start exercise 4 hours before their habitual bedtime on each of the three evenings; 3. No exercise - subject will watch television or read and they will be required to remain sedentary.