CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 36 enrolled
Drug / intervention
Perifosine +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01051557
NCT01051557Phase 2Completed
CompareCT.gov

Phase I/II Trial of Temsirolimus and Perifosine for Recurrent or Progressive Malignant Gliomas

National Cancer Institute (NCI)·interventional·Posted Jan 18, 2010·Updated Jul 19, 2021

In Brief

A Phase 2 clinical trial evaluating Laboratory Biomarker Analysis, Perifosine, and 2 other interventions for Adult Anaplastic Astrocytoma and 8 related conditions. Completed, enrolled 36 participants across 1 site.

Detailed Summary

This phase I/II trial studies the side effects and best dose of temsirolimus when given together with perifosine and to see how well it works in treating patients with recurrent or progressive malignant glioma. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as perifosine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving temsirolimus with perifosine may be an effective treatment for malignant glioma.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAdult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Diffuse Astrocytoma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Mixed Glioma, Adult Oligodendroglioma, Recurrent Adult Brain Neoplasm
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedJan 18, 2010
Enrollment StartJan 27, 2010
Primary CompletionNov 16, 2018
Study CompletionSep 30, 2020
TodayJul 2, 2026
Enrollment to primary: 8.8 yearsPosted 16.5 years ago

Interventions

Laboratory Biomarker Analysisother

Correlative studies

Perifosinedrug

Given PO

Temsirolimusdrug

Given IV

Therapeutic Conventional Surgeryprocedure

Undergo cytoreductive surgery