CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
Placebo sildenafil +1 moredrug
Likely dose
Sildenafil 25mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01059994
NCT01059994N/ACompleted
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Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability

The University of Texas Medical Branch, Galveston·interventional·Posted Feb 1, 2010·Updated Feb 11, 2019

In Brief

A clinical study evaluating Placebo sildenafil and Sildenafil for Fatigue and Aging. Completed, enrolled 12 participants across 1 site.

Detailed Summary

This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older individuals. We propose to test a new method that may enable simultaneous determination of both vascular and skeletal muscle NO production for the first time in humans. Further, we will determine whether augmentation of NO-mediated responses, by administration of sildenafil citrate (Viagra), reduces fatigue and fatigability in older individuals.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsFatigue, Aging
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedFeb 1, 2010
Enrollment StartJan 1, 2010
Primary CompletionJul 1, 2013
TodayJul 2, 2026
Enrollment to primary: 3.5 yearsPosted 16.4 years ago

Interventions

Placebo sildenafildrug

Oral, daily, 1 week.

Sildenafildrug

oral, 25mg, daily for 1 week