CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 41 enrolled
Drug / intervention
Alisertib +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01094288
NCT01094288Phase 1Completed

A Phase 1 Study of MLN8237, an Aurora A Kinase Inhibitor, in Patients With Advanced Solid Tumors Including Castration-Resistant Prostate Cancer Receiving a Standard Docetaxel Regimen

Millennium Pharmaceuticals, Inc.·interventional·Posted Mar 26, 2010·Updated Feb 15, 2019

In Brief

A Phase 1 clinical trial evaluating Alisertib and Docetaxel for Advanced Solid Tumors and Adenocarcinoma of the Prostate. Completed, enrolled 41 participants across 4 sites.

Detailed Summary

The purpose of this study is to evaluate the safety and tolerability of alisertib in combination with docetaxel as a treatment for participants with advanced solid tumors, including castration-resistant prostate cancer, who were deemed by the investigator to be medically appropriate candidates for docetaxel therapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedMar 26, 2010
Enrollment StartAug 17, 2010
Primary CompletionFeb 28, 2014
Study CompletionJan 4, 2017
TodayJul 2, 2026
Enrollment to primary: 3.5 yearsPosted 16.3 years ago

Interventions

Alisertibdrug

Alisertib ECT

Docetaxeldrug

Docetaxel IV infusion