At a glance
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Investigation of Analgesic and Anti-inflammatory Effects of Beta-adrenergic Antagonist Propranolol
In Brief
A clinical study evaluating Alfentanil, Propranolol, and 1 other intervention for Pain Measurement. Completed, enrolled 10 participants across 1 site.
Detailed Summary
Previous studies have shown that the beta-adrenergic system plays a role in processing pain and the expression of hyperalgesia. Recent studies have investigated the analgesic effects, and potential anti-hyperalgesic effects (using a model of opioid induced (OIH) hyperalgesia) of propranolol, a beta adrenergic antagonist. We plan to further investigate the analgesic effects, and the potential anti inflammatory effects, of propranolol and compare those effects to alfentanil, an opioid of known effect, and placebo
Study Details
Timeline
Interventions
An infusion of alfentanil 100ng/ml was administered over 3 hours using a programmable infusion pump.
An infusion of propranolol 30ng/ml was administered over 3 hours using a programmable infusion pump.
An infusion of normal saline was administered over 3 hours using a programmable infusion pump to mimic the 2 drug arms,