At a glance
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Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated With Initial Radical Hysterectomy and Pelvic Lymphadenectomy (NCT #01101451)
In Brief
A Phase 3 clinical trial evaluating Cisplatin, External Beam Radiation Therapy, and 4 other interventions for Cervical Adenocarcinoma and 6 related conditions. Completed, enrolled 340 participants across 719 sites in 3 countries.
Detailed Summary
This randomized phase III trial studies radiation therapy with chemotherapy to see how well they work compared to radiation therapy alone in treating patients with stage I-IIA cervical cancer who previously underwent surgery. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving radiation therapy together with chemotherapy is more effective than radiation therapy alone in treating patients with cervical cancer.
Study Details
Timeline
Interventions
Given IV
Undergo radiotherapy
Undergo radiotherapy
Correlative studies
Ancillary studies
Ancillary studies