At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Pharmacotoxicology of Trichloroethylene Metabolites Aim 3
In Brief
A Phase 2 clinical trial evaluating Dichloroacetate environmental dose, Chloral Hydrate environmental dose, and 2 other interventions for Healthy. Completed, enrolled 27 participants across 1 site.
Detailed Summary
This is a research study to look at how Dichloroacetate (DCA), and investigational drug and chloral hydrate are broken down in the body. The purpose of the study is to better understand how humans metabolize these two common chemicals that are widely present in the environment. The study focuses on how the drug chloral hydrate is broken down and how it effects DCA
Study Details
Timeline
Interventions
On day 6 they receive Dichloroacetate 2.5 ug/kg orally times 1 and have pharmacokinetics.
Study subjects are given 1.5 ug/kg of Chloral Hydrate for 5 nights and pharmacokinetics are done on night 1 and 5.
Subjects receive 25 mg/kg DCA on Day 6. Pharmacokinetics are done on nights 1 and nights 5.
Subject is given 25 mg/kg of Chloral Hydrate for five nights.