At a glance
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Modafinil, Sleep Architecture and Cocaine Relapse
In Brief
A Phase 2 clinical trial evaluating Modafinil and Cognitive Behavioral Therapy for Cocaine Dependence. Completed, enrolled 114 participants across 1 site.
Detailed Summary
The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users. The investigators hypothesize that the beneficial effects of modafinil in reducing cocaine use may be related to specific effects modafinil has on sleep. This study will measure sleep and cocaine use in cocaine dependent persons who are trying to stop using cocaine, and will test the connection between modafinil's effects on sleep and cocaine use.
Study Details
Timeline
Interventions
Modafinil 400mg PO QDaily following up-titration for \~8weeks
Once weekly cognitive behavioral therapy for cocaine dependence