CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 17 enrolled
Drug / intervention
celecoxib +7 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01158534
NCT01158534Phase 2Completed
CompareCT.gov

A Phase II Trial of Celecoxib Plus Interferon Alpha in Metastatic Renal Cell Carcinoma Patients With 3+ COX-2 Tumor Immunostaining

Case Comprehensive Cancer Center·interventional·Posted Jul 8, 2010·Updated Aug 7, 2012

In Brief

A Phase 2 clinical trial evaluating celecoxib, recombinant interferon alfa-2b, and 6 other interventions for Renal Cell Cancer and Stage IV Renal Cell Cancer. Completed, enrolled 17 participants across 1 site.

Detailed Summary

RATIONALE: Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Recombinant interferon alfa-2b may interfere with the growth of cancer cells and slow the growth of kidney cancer. Giving celecoxib together with recombinant interferon alpha-2b may kill more tumor cells and be an effective treatment for metastatic kidney cancer. PURPOSE: This phase II trial is studying how well giving celecoxib together with recombinant interferon alfa-2b works in treating patients with metastatic kidney cancer who have undergone surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsRenal Cell Cancer, Stage IV Renal Cell Cancer
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJul 8, 2010
Enrollment StartMar 1, 2006
Primary CompletionSep 1, 2010
Study CompletionOct 1, 2010
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 16.0 years ago

Interventions

celecoxibdrug

Given orally

recombinant interferon alfa-2bbiological

Given subcutaneously

polymerase chain reactionother

Correlative studies

laboratory biomarker analysisother

Correlative studies

reverse transcriptase-polymerase chain reactionother

Correlative studies

immunologic techniqueother

Correlative studies

immunohistochemistry staining methodother

Correlative studies

flow cytometryother

Correlative studies