At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized, Placebo-controlled, Concealed Allocation Comparison of Respiratory Depression and Coughing During Bronchoscopy With Dexmedetomidine-ketamine as an Adjunct to Fentanyl-midazolam Sedation
In Brief
A Phase 4 clinical trial evaluating Dexmedetomidine load, Ketamine load, and 7 other interventions for Sedation. Completed, enrolled 50 participants across 1 site.
Detailed Summary
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.
Study Details
Timeline
Interventions
Dexmedetomidine 1 µg/kg prior to bronchoscopy
Ketamine 30 mg bolus prior to bronchoscopy
2 mg bolus prior to bronchoscopy
50 µg bolus prior to bronchoscopy
0.5 µg/kg/hour for the duration of bronchoscopy (58.5 minutes average)
8 µg/kg/min for the duration of bronchoscopy (58.5 minutes average)
0.5 mg demand bolus at discretion of pulmonologist
12.5 µg demand bolus at discretion of pulmonologist
25 mg bolus after 6th and 13th demand midazolam/fentanyl bolus