CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 121 enrolled
Drug / intervention
dexamethasone +2 moredrug
Likely dose
dexamethasone 40mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01159574
NCT01159574Phase 2Completed
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A Phase II Study of Dexamethasone (DECADRON®), Clarithromycin (BIAXIN®), and Pomalidomide (CC-4047®) for Subjects With Relapsed or Refractory Multiple Myeloma

Weill Medical College of Cornell University·interventional·Posted Jul 9, 2010·Updated Jun 11, 2019

In Brief

A Phase 2 clinical trial evaluating dexamethasone, clarithromycin, and 1 other intervention for Multiple Myeloma. Completed, enrolled 121 participants across 1 site.

Detailed Summary

This study is intended to investigate the combination of the combination of dexamethasone (Decadron®), Clarithromycin (Biaxin®), and pomalidomide (CC-4047®) \[ClaPd\] in multiple myeloma patients who have relapsed or refractory disease who have failed prior treatment with lenalidomide when used alone or in combination with corticosteroids. Primary endpoint will be response rate to treatment. Secondary endpoints will include toxicity of the combination, time to maximum response, and time to disease progression

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMultiple Myeloma
CountriesUnited States
CollaboratorsCelgene

Timeline

Phase 2CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJul 9, 2010
Enrollment StartAug 1, 2010
Primary CompletionMay 5, 2015
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 16.0 years ago

Interventions

dexamethasonedrug

40mg will be given on days 1, 8, 15, 22 of a 28-day cycle

clarithromycindrug

orally at a dose of 500 mg twice a day on days 1-28 of a 28 day cycle

Pomalidomidedrug

orally 4mg daily for days 1-21 of each 28 day cycle