At a glance
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The Importance of Anti-anaerobic Therapy for Acute PID
In Brief
A Phase 2 clinical trial evaluating Ceftriaxone, Doxycycline, and 2 other interventions for Pelvic Inflammatory Disease. Completed, enrolled 233 participants across 3 sites.
Detailed Summary
This study is a randomized placebo-controlled trial comparing two antibiotic treatment regimens for acute PID. Women with acute PID will be randomized to one of two treatment regimens: 1) a single intramuscular dose of ceftriaxone 250 mg, doxycycline 100 mg orally twice a day for 14 days, along with placebo tablets orally twice a day for 14 days or 2) same doses of ceftriaxone and doxycycline, and metronidazole 500 mg orally twice a day for 14 days. The primary objective is to compare the eradication of anaerobic organisms from the upper genital tract between women who receive standard outpatient antibiotic treatment to those who receive standard outpatient treatment along with a two-week course of metronidazole.
Study Details
Timeline
Interventions
ceftrixone 250mg IM single dose
Doxycycline 100 mg PO bid x 14 days
metronidazole 500 mg PO bid x 14 days
placebo oral capsule PO bid x 14 days