CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 25 enrolled
Drug / intervention
decitabine +7 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01165996
NCT01165996Phase 2Completed
CompareCT.gov

A Proof of Concept Study of Non-DNA Damaging DNMT1 Depletion Therapy for Myelodysplastic Syndrome

Case Comprehensive Cancer Center·interventional·Posted Jul 20, 2010·Updated Mar 4, 2019

In Brief

A Phase 2 clinical trial evaluating flow cytometry, DNA methylation analysis, and 6 other interventions for Chronic Myelomonocytic Leukemia and 7 related conditions. Completed, enrolled 25 participants across 2 sites.

Detailed Summary

RATIONALE: Decitabine may help myelodysplastic cells become more like normal stem cells. PURPOSE: This clinical trial studies differentiation therapy with decitabine in treating patients with myelodysplastic syndrome.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes, Myelodysplastic Syndromes, Refractory Anemia, Refractory Anemia With Excess Blasts, Refractory Anemia With Ringed Sideroblasts, Refractory Cytopenia With Multilineage Dysplasia, Thrombocytopenia
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2011201220132014201520162017201820192020202120222023202420252026
First PostedJul 20, 2010
Enrollment StartJul 1, 2010
Primary CompletionDec 1, 2011
Study CompletionAug 1, 2012
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 16.0 years ago

Interventions

flow cytometryother

Correlative studies

DNA methylation analysisother

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cytogenetic analysisother

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decitabinedrug

Given subcutaneously

microarray analysisgenetic

Correlative studies

gene expression analysisgenetic

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pharmacological studyother

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polymorphism analysisgenetic

Correlative studies