CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 15 enrolled
Drug / intervention
Saliva sample collectionother
Likely dose
Not stated in record
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Search/NCT01167504
NCT01167504N/ACompleted

Investigating the Formation of Salivary Films and How They Change in the Presence of Ingredients From Food and Oral Hygiene Products

Quadram Institute Bioscience·observational·Posted Jul 22, 2010·Updated Jan 6, 2014

In Brief

An observational study evaluating Saliva sample collection for Healthy. Completed, enrolled 15 participants across 1 site.

Detailed Summary

The aim of this study is to determine how different ingredients which are found in food and other consumer products affect the ability of saliva to form surface films. Saliva forms a protective film on the surfaces inside the mouth. This film affects the way we consume and digest food and protects our teeth and other surfaces inside the mouth from disease and decay. It is not well known how this film forms, or which components in everyday life affect formation of the film, and therefore its protective properties. Samples of saliva will be collected from apparently healthy volunteers. The properties of the film (thickness, density, strength, protein composition) will be studied in the laboratory under controlled conditions. The effects of common ingredients in foods and other products such as proteins, emulsifiers, preservatives and surfactants on the formation and properties of the film will be determined. The results of this study will help us to understand how different ingredients can change the properties of saliva that may affect the way that we sense and digest food, and the ability of saliva to protect against decay and infection. This could, in the future lead to new ideas for developing:healthy foods (e.g. lower fat) that taste better, or more effective dental care products.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy
CountriesUnited Kingdom
CollaboratorsGlaxoSmithKline

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedJul 22, 2010
Enrollment StartJun 1, 2010
Primary CompletionApr 1, 2013
Study CompletionAug 1, 2013
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 15.9 years ago

Interventions

Saliva sample collectionother

Collection of either whole mouth saliva or parotid saliva. Whole mouth saliva is collected through stimulation by inert gum. Parotid saliva is collected by using a Lashley cup placed over the parotid duct and stimulated by a fruit sweet.