At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Does Hemodynamic Optimization During and After Colorectal Surgery Result in Improved Intestinal Perfusion, Sustained Intestinal Barrier and Improved Postoperative Recovery?
In Brief
A Phase 4 clinical trial evaluating Goal-directed fluid optimization and Regimen based on expertise anaesthesist for Colorectal Carcinoma. Completed, enrolled 58 participants across 1 site.
Detailed Summary
58 patients undergoing surgery of the large bowel are divided into two groups. The control group will receive standard care. The intervention group will receive standard care plus optimization of the blood circulation based on in- or decrease of the output of the heart. Between group differences are measured primarily by markers of intestinal damage in plasma and urine. Also CO2 pressure in the stomach lumen is measured (reflecting blood supply to the gut). The investigators hypothesize that the intervention group will have less intestinal damage, improved blood supply to the bowel and improved recovery of the operation compared to the control group.
Study Details
Timeline
Interventions
Fluid administration and optimization based on cardiac output findings during surgery and during the first 8 hours of the postoperative phase.
Fluid regimen based on expertise anaesthesist