At a glance
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Genetic Analysis of Familial Cases of Premature Ovarian Failure
In Brief
An observational study for Familial Premature Ovarian Failure. Completed, enrolled 110 participants across 2 sites.
Detailed Summary
The Premature ovarian failure (POF) is a rare syndrome observed in women under 40 who induced estrogen deficiency and often leads to infertility final. The etiologies of POF remain unknown in more than 85% of cases. There are 5-10 % of familial cases.The main objective of this study is to recruit, phenotype and genotype 20 families with at least two subjects with nonsyndromic POF in order to identify new loci using a single technical standard nucleotide polymorphisms (SNPs). This study will also include related population and population control.